Scientists have found that a protein abundant in embryonic stem cells plays a major role in cancer, which they claim offers a possible new target for drug development.
A team at the Stem Cell Program at Children's Hospital Boston, led by Indian-origin scientist Srinivas Viswanathan, has discovered that LIN28 protein can transform cells to a cancerous state, and that it is abundant in a variety of advanced human cancers like liver cancer and ovarian cancer.
According to them, LIN28 and a related protein, LIN28B, may be involved in some 15 per cent of human cancers. By blocking or suppressing LIN28, it might be possible to revive the let-7 family's natural tumour-suppressing action. "LIN28 is a fascinating protein that acts in stem cells and cancers, and is teaching us that cancer is often a disease of stem cells,"
LIN28 and LIN28B Protein in stem cells correlated to cancer
Scientists have found that a protein abundant in embryonic stem cells plays a major role in cancer, which they claim offers a possible new target for drug development.
A team at the Stem Cell Program at Children's Hospital Boston, led by Indian-origin scientist Srinivas Viswanathan, has discovered that LIN28 protein can transform cells to a cancerous state, and that it is abundant in a variety of advanced human cancers like liver cancer and ovarian cancer.
According to them, LIN28 and a related protein, LIN28B, may be involved in some 15 per cent of human cancers. By blocking or suppressing LIN28, it might be possible to revive the let-7 family's natural tumour-suppressing action. "LIN28 is a fascinating protein that acts in stem cells and cancers, and is teaching us that cancer is often a disease of stem cells,"
A team at the Stem Cell Program at Children's Hospital Boston, led by Indian-origin scientist Srinivas Viswanathan, has discovered that LIN28 protein can transform cells to a cancerous state, and that it is abundant in a variety of advanced human cancers like liver cancer and ovarian cancer.According to them, LIN28 and a related protein, LIN28B, may be involved in some 15 per cent of human cancers. By blocking or suppressing LIN28, it might be possible to revive the let-7 family's natural tumour-suppressing action. "LIN28 is a fascinating protein that acts in stem cells and cancers, and is teaching us that cancer is often a disease of stem cells,"
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